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This website is visited by PhD students and post-doctoral scientists from several Belgian Faculties of Medicine: Université Libre de Bruxelles (ULB), Université Catholique de Louvain (UCL), and Université de Liège (ULg).

To post a position for free, please submit your proposal here .

 Communiquez ici les possibilités de recherche !

Ce portail est visité par les doctorants et post-doctorants des facultés de médecine de l'Université Catholique de Louvain (UCL), de l'Université Libre de Bruxelles (ULB), de l'Université de Liège (ULg) voire d'autres horizons... Vous désirez communiquer une possibilité de mener des travaux de recherches dans votre laboratoire (mémoire, doctorat et post-doctorat) ? Dans ce cas, contactez-nous, nous afficherons gratuitement votre offre dans cet espace !

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 #8 - June 08 : Research project : epigenomics of placenta
POST DOCTORAL POSITION Nutritional epigenomics of placenta: impact of unbalanced diets on transcriptionnal regulation and epigenetic patterns in rodents and humans A two years postdoctoral position is available at Inserm U781: « Genetics and epigenetics of metabolic diseases, neurosensorial diseases and development ». Claudine Junien, Professor of Genetics, Co-Director of Inserm UR 781. Hôpital Necker - Enfants Malades, Paris, France. Scientific project Unbalanced diet and metabolic disturbances associated with a significant and increasing proportion of women who are overweight and overfed when pregnant increase the risk of epigenetic and metabolic malprogramming for the fetus - giving rise to the metabolic syndrome (MetS) in adulthood. As for fetus growth and development, complex epigenetically controlled mechanisms are required for placental development. Nutrition can affect these epigenetic mechanisms, causing long-term changes in gene expression and malprogramming. Thus, improving the nutritional environment to which an individual is exposed during development represents a major health challenge for future generations. The aim of this project, which is already in progress, is : 1) - to identify differentially expressed placental murine genes according to the physiopathological and nutritional status of the mother; 2) – to identify diet-specific and sex-specific epigenomic signatures in relevant gene promoters and/or repetitive sequences that would allow us to identify candidate targets for dietary interventions : transcription factors and/or chromatin remodeling factors. 3) - to transfer to human placentae – from 6 cohorts covering the spectrum of physiopathological and nutritional conditions associated with malprogramming - data thus acquired with experimental rodent models, by functional genomics and epigenomics approaches. Appropriate human placentae markers would allow us to trace back the in utero journey, but also would serve as new biological predictors of responses to nutritional interventions. Expected profile The postdoctoral fellow should have a good expertise in epigenetics signatures analyses i.e. DNA methylation and histone modifications (chromatin immunoprecipitation). Experience and contacts in one or more of the following fields will be an advantage : epigenetics developmental programming, obesity, type 2 diabetes, metabolic syndrome, nutrition, placenta, and animal models. The eligible candidate will be funded for one year renewable by a grant. The salary will be between 1830 € and 2500 €, depending upon the candidate. This research program is presently funded by grants from ANR (Agence Nationale pour la Recherche) and FCA (Fondation Coeur et Artère) to a 5 teams network on rodent and human placentas coordinated by our lab. The position is available immediately. Contact Applicants should send a covering letter outlining their suitability for this position, along with their CV, either by email to HYPERLINK "mailto:junien@necker.fr" junien@necker.fr HYPERLINK "mailto:/claudine.junien@necker.fr" /claudine.junien@inserm.fr or by post to Pr Claudine Junien, Inserm UR 781 Hôpital Necker - Enfants Malades, Clinique M. Lamy 149 rue de Sèvres 75015 Paris France.
 #7 Fev 08 - INSERM U 871

POST DOCTORAL POSITION Nutritional epigenomics of placenta: impact of unbalanced diets on transcriptionnal regulation and epigenetic patterns in rodents and humans A two years postdoctoral position is available at Inserm U781 : « Genetics and epigenetics of metabolic diseases, neurosensorial diseases and development ». Claudine Junien, Professor of Genetics, Co-Director of Inserm UR 781. Hôpital Necker - Enfants Malades, Paris, France.

Scientific project Unbalanced diet and metabolic disturbances associated with a significant and increasing proportion of women who are overweight and overfed when pregnant increase the risk of epigenetic and metabolic malprogramming for the fetus - giving rise to the metabolic syndrome (MetS) in adulthood. Despite the important role of placenta in the exchange of nutrients between the mother and the fetus and the fact that the placenta is one the very rare tissues that can be easily sampled and in great quantities, there are still very few investigations on its role in nutritional adaptative processes. As for fetus growth and development, complex epigenetically controlled mechanisms are required for placental development. Nutrition can affect these epigenetic mechanisms, causing long-term changes in gene expression and malprogramming. Thus, improving the nutritional environment to which an individual is exposed during development represents a major health challenge for future generations. The aim of this project, which is already in progress, is : 1) - to identify differentially expressed placental murine genes according to the physiopathological and nutritional status of the mother; 2) – to decipher the « epigenetic signatures » associated with these transcriptional changes, and their potential reversibility; 3) - to transfer to human placentae – from 6 cohorts covering the spectrum of physiopathological and nutritional conditions associated with malprogramming - data thus acquired with experimental rodent models, by functional genomics and epigenomics approaches. Appropriate human placentae markers would allow us to trace back the in utero journey, but also would serve as new biological predictors of responses to nutritional interventions. Expected profile We are looking for a dynamic and highly motivated postdoctoral fellow. He or she should have a good expertise in gene expression analysis (transcriptomic signature, Q RTPCR, in situ hybridization) and bioinformatic tools, in epigenetics signatures analysis, and in animal experiments (the authorization to manipulate alive animals would be welcome, level 1 for French students). Experience and contacts in one or more of the following fields will be an advantage: microarray analysis & bioinformatic and biostatistic tools and epigenetics developmental programming, obesity, type 2 diabetes, metabolic syndrome, nutrition, placenta, and animal models,. The eligible candidate will be funded for two years by a grant. The salary will be between 1830 € and 2500 €, depending upon the candidate. The position is available immediately. Contact Applicants should send a covering letter outlining their suitability for this position, along with their CV, either by email to junien@necker.fr or by post to Pr Claudine Junien, Inserm UR 781 Hôpital Necker - Enfants Malades, Clinique M. Lamy 149 rue de Sèvres 75015 Paris France.

 #5 June 07 - Lab Recherche en Reproduction Humaine (ULB)

Le laboratoire de Recherche en Reproduction Humaine (Erasme/ULB) cherche un jeune médecin brillant et intéressé à développer un projet de recherche destiné à mener à une thèse de doctorat dans le domaine des cellules souches embryonnaires et la mucoviscidose.

Ce projet comporterait, au cours de l’année académique qui vient, un stage de 9 mois dans un laboratoire de recherche de premier plan mondial dans le domaine des cellules souches embryonnaires en Australie suivi de deux à quatre années de recherche au Laboratoire de Reproduction Humaine sur le Campus Erasme. 

Un tel projet implique donc un investissement important en recherche et nécessite une certaine passion sinon une passion certaine pour celle-ci. 

Pourriez-vous me faire savoir dans les délais les plus brefs si vous êtes intéressés ou non sans trop tenir compte des contraintes administratives ? 

Pour ce qui concerne les changements de plans de stage, les financements de recherche, je vous rencontrerais personnellement pour vous donner plus d’information et pour discuter des possibilités en tenant compte de votre parcours. 

Bien cordialement, 
 
Professeur Yvon Englert MD PhD 
Université Libre de Bruxelles 
Chef de Service de Gynécologie-Obstétrique - Hôpital Erasme 
Directeur du laboratoire de recherche en reproduction humaine 
Président du MC/DES de Gynécologie-Obstétrique 
Vice-Doyen elect

Possibilités de contacts :

Laboratoire de recherche en reproduction humaine
tel +32-2-555.63.58, fax +32-2-555.65.02, fertilab@ulb.ac.be
Campus hospitalo-universitaire d'Anderlecht, Bâtiment GE 2 2210, campus erasme
CP636, route de Lennik 808, 1070 Bruxelles

Professeur Yvon ENGLERT
tel 02 555 63 58, fax 02 555 62 05, yenglert@ulb.ac.be
Campus hospitalo-universitaire d'Anderlecht
CP636, route de Lennik 808, 1070 Bruxelles
 #4 May07 - Lab of Experimental Medicine (ULB) - Call for applications for a PhD position
Applications are invited for a PhD position at the Laboratory of Experimental Medicine at the Universite Libre de Bruxelles, Brussels, Belgium.

We study molecular mechanisms of free fatty acid-induced pancreatic beta-cell dysfunction and death in type 2 diabetes (see Cnop M et al. Diabetes, 54 (Suppl. 2): S97-S107, 2005 and Cnop M et al. J Biol Chem, 282: 3989-3997, 2007). Experience in molecular and cell biology is a plus.

Please email a letter of interest and curriculum vitae to:
Miriam Cnop or Decio L. Eizirik
Laboratory of Experimental Medicine Faculty of Medicine Universite Libre de Bruxelles Brussels, Belgium

After pre-selection, some of the candidates will be invited for an interview.
 #3 March 07 - Laboratory of Human Genetics of Infectious Diseases, Paris, France

Three post-doctoral research positions in Human Genetics of Infectious Diseases

Applications are invited for three Postdoctoral Research Fellows to join the Laboratory of Human Genetics of Infectious Diseases at Necker Hospital and Research Centre. This laboratory is a world leader in the field of Human Genetics of Infectious Diseases as demonstrated by its main recent publications (Alcais et al. Nature Genetics 2007; Casrouge et al. Science. 2006; Vogt et al. Nature Genetics 2005 ;  Mira et al, Nature 2004; Picard et al, Science 2003 ; Dupuis et al, Science 2001)

 

The fellows would explore the molecular genetic basis of human infectious diseases, following candidate-gene and/or genome-wide approaches. Depending on the applicant’s scientific interest, her/his project may aim to decipher a novel primary immunodeficiency or to exploit known genetic defects for immunological purposes. Monogenic and/or complex traits may be studied. Infectious diseases investigated in the laboratory include mycobacterial, pneumococcal, and herpetic diseases.

 

The Laboratory of Human Genetics of Infectious Diseases is international. The two languages of communication in the laboratory are French and English. About one third of the 24 laboratory’s members are French. The others originate from 10 countries from Europe, the Americas, Africa, and Asia.

 

No specific medical and/or scientific qualification is requested, besides either doctoral degree. A strong motivation is an absolute must. Independent and interactive candidates are preferred.

 

A post-doctoral salary will be guaranteed for at least three years. Candidates should send their CV, cover letter, statements of current and future research interests (1 page), publication track record and the names and addresses/e-mails contacts of at least two academic referees. For informal inquiries please contact casanova@necker.fr or abel@necker.fr .

 

Please send full application to:

Pr. Jean-Laurent Casanova

Director, Laboratory of Human Genetics of Infectious Diseases

University of Paris René Descartes-INSERM U550

Necker-Enfants Malades Medical School

156 rue de Vaugirard

75015 Paris, France, EU

Voice 33 1 40 61 56 87 (office) or 53 81 (secretary)

Fax 33 1 40 61 56 88

E-mail casanova@necker.fr

web site : http://www.hgid.net

 #2 Lab Génétique Humaine des Maladies Infectieuses - Paris

Une position post-doctorale est disponible au laboratoire de Génétique Humaine des Maladies Infectieuses, Faculté de Médecine Necker, Paris pour travailler sur un projet de génétique épidémiologique de la tuberculose. Le projet se déroule en étroite collaboration avec l’Institut Pasteur de Tananarive à Madagascar.

Le/La post-doctorant(e) aura un rôle de coordination entre les deux laboratoires et devra passer la majorité de son temps à Madagascar. Le profil est soit celui d’un médecin avec une expertise en épidémiologie et/ou maladies infectieuses, soit celui d’un doctorant en immunologie ou génétique humaine. Le poste est pour une durée minimale de 18 mois pouvant être prolongée.

Les candidats intéressés peuvent adresser leur CV, lettre de motivation, liste de publications, et coordonnées de deux personnes de référence à :

 

Laurent Abel

Laboratoire de Génétique Humaine des Maladies Infectieuses,

Université de Paris René Descartes-INSERM U550

Faculté de Médecine Necker

156 rue de Vaugirard

75015 Paris, France,

Tel. 33 1 40 61 56 87 (bureau) ou 53 81 (secrétariat)

Fax 33 1 40 61 56 88

E-mail abel@necker.fr

web site : http://www.hgid.net